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</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">Subtilosin_A</th></tr><tr><td colspan="2" class="infobox-image"><div class="infobox-caption">structure of Subtilosin A</div></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd; background-color: light-dark(#ddd, #404244) !important; color:inherit;">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; background-color: light-dark(#e7dcc3, #332c1a) !important; color:inherit;">Symbol</th><td class="infobox-data" style="background-color: #eee; background-color: light-dark(#eee, #27292d) !important; color:inherit;">Subtilosin_A</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; background-color: light-dark(#e7dcc3, #332c1a) !important; color:inherit;"><a href="Pfam" title="Pfam">Pfam</a></th><td class="infobox-data pfam" style="background-color: #eee; background-color: light-dark(#eee, #27292d) !important; color:inherit;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/pfam/PF11420">PF11420</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; background-color: light-dark(#e7dcc3, #332c1a) !important; color:inherit;"><a href="InterPro" title="InterPro">InterPro</a></th><td class="infobox-data" style="background-color: #eee; background-color: light-dark(#eee, #27292d) !important; color:inherit;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/IPR021539">IPR021539</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; background-color: light-dark(#e7dcc3, #332c1a) !important; color:inherit;"><a href="TCDB" class="mw-redirect" title="TCDB">TCDB</a></th><td class="infobox-data" style="background-color: #eee; background-color: light-dark(#eee, #27292d) !important; color:inherit;"><a rel="nofollow" class="external text" href="http://www.tcdb.org/search/result.php?tc=1.C.84">1.C.84</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; background-color: light-dark(#e7dcc3, #332c1a) !important; color:inherit;"><a href="Orientations_of_Proteins_in_Membranes_database" title="Orientations of Proteins in Membranes database">OPM superfamily</a></th><td class="infobox-data" style="background-color: #eee; background-color: light-dark(#eee, #27292d) !important; color:inherit;"><a rel="nofollow" class="external text" href="https://opm.phar.umich.edu/protein_superfamilies/379">379</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; background-color: light-dark(#e7dcc3, #332c1a) !important; color:inherit;"><a href="Orientations_of_Proteins_in_Membranes_database" title="Orientations of Proteins in Membranes database">OPM protein</a></th><td class="infobox-data" style="background-color: #eee; background-color: light-dark(#eee, #27292d) !important; color:inherit;"><a rel="nofollow" class="external text" href="https://opm.phar.umich.edu/proteins?search=1pxq">1pxq</a></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee; background-color: light-dark(#eee, #27292d) !important; color:inherit;"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd; color:inherit;">Available protein structures:</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; color:inherit; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="Pfam" title="Pfam">Pfam</a>
</th><td class="infobox-data" style="background-color: #eee; color:inherit; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="http://pfam.xfam.org/family/PF11420?tab=pdbBlock">structures</a> / <a rel="nofollow" class="external text" href="http://prodata.swmed.edu/ecod/complete/search?kw=PF11420">ECOD</a>
</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; color:inherit; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td class="infobox-data" style="background-color: #eee; color:inherit; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_annotation.annotation_id:PF11420%20AND%20rcsb_polymer_entity_annotation.type:Pfam">RCSB PDB</a>; <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/entry/search/index?pfam_accession:PF11420">PDBe</a>; <a rel="nofollow" class="external text" href="https://pdbj.org/search/pdb?other_db_select=PFam&other_db_field=PF11420">PDBj</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; color:inherit; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="PDBsum" title="PDBsum">PDBsum</a></th><td class="infobox-data" style="background-color: #eee; color:inherit; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPfamStr.pl?pfam_id=PF11420">structure summary</a></td></tr></tbody></table></td></tr></tbody></table>
<p><b>Microcins</b> are very small <a href="Bacteriocin" title="Bacteriocin">bacteriocins</a>, composed of relatively few <a href="Amino_acid" title="Amino acid">amino acids</a>. For this reason, they are distinct from their larger <a href="Protein" title="Protein">protein</a> cousins. The classic example is microcin V, of <i><a href="Escherichia_coli" title="Escherichia coli">Escherichia coli</a></i>. Subtilosin A is another bacteriocin from <i><a href="Bacillus_subtilis" title="Bacillus subtilis">Bacillus subtilis</a></i>. The <a href="Peptide" title="Peptide">peptide</a> has a cyclized backbone and forms three cross-links between the sulphurs of Cys13, Cys7 and Cys4 and the alpha-positions of Phe22, Thr28 and Phe31.<sup id="cite_ref-pmid15035610_1-0" class="reference"><a href="#cite_note-pmid15035610-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
</p><p>Microcins produced by <a href="Commensal" class="mw-redirect" title="Commensal">commensal</a> <i>E. coli</i> strains target and eliminate <a href="Enteric" class="mw-redirect" title="Enteric">enteric</a> pathogens such as <i><a href="Salmonella_enterica" title="Salmonella enterica">Salmonella enterica</a></i> by mimicking the <a href="Siderophore" title="Siderophore">siderophores</a> the pathogens use for iron scavenging.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Microcins also help commensal strains of <i>E. coli</i> outcompete pathogenic strains.<sup id="cite_ref-pmid27798599_3-0" class="reference"><a href="#cite_note-pmid27798599-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>
</p><p>BACTIBASE<sup id="cite_ref-Hammami_2007_4-0" class="reference"><a href="#cite_note-Hammami_2007-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Hammami_2010_5-0" class="reference"><a href="#cite_note-Hammami_2010-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> database is an open-access database for bacteriocins including microcins.
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<div class="mw-heading mw-heading2"><h2 id="References">References</h2></div>
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<li id="cite_note-pmid27798599-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid27798599_3-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFSassone-Corsi_M,_Nuccio_SP,_Liu_H,_Hernandez_D,_Vu_CT,_Takahashi_AA2016" class="citation journal cs1">Sassone-Corsi M, Nuccio SP, Liu H, Hernandez D, Vu CT, Takahashi AA; et al. (2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145735">"Microcins mediate competition among Enterobacteriaceae in the inflamed gut"</a>. <i>Nature</i>. <b>540</b> (7632): <span class="nowrap">280–</span>283. <a href="Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2016Natur.540..280S">2016Natur.540..280S</a>. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnature20557">10.1038/nature20557</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5145735">5145735</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27798599">27798599</a>.</cite><span class="cs1-maint citation-comment"><code class="cs1-code">{{cite journal}}</code>: CS1 maint: multiple names: authors list (link)</span> </span>
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<li id="cite_note-Hammami_2010-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-Hammami_2010_5-0">^</a></b></span> <span class="reference-text"><cite id="CITEREFHammamiZouhirLe_LayBen_Hamida2010" class="citation journal cs1">Hammami R, Zouhir A, Le Lay C, Ben Hamida J, Fliss I (2010). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824694">"BACTIBASE second release: a database and tool platform for bacteriocin characterization"</a>. <i>BMC Microbiology</i>. <b>10</b>: 22. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1186%2F1471-2180-10-22">10.1186/1471-2180-10-22</a></span>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824694">2824694</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20105292">20105292</a>.</cite></span>
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This article is issued from <a class="external text" title="Last edited on 2025-07-16" href="https://en.wikipedia.org/wiki/?title=Microcin&oldid=1300814700">Wikipedia</a>. The text is available under <a class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.en">Creative Commons Attribution-Share Alike 4.0</a> unless otherwise noted. Additional terms may apply for the media files.
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